Nirmitee.io

Healthcare interoperability company

Healthcare Interoperability Solutions and Services

We engineer the connections between EHRs, payers, labs, pharmacies, devices and your product: FHIR R4 APIs, HL7 v2 interfaces, X12 EDI, C-CDA and DICOM, built to CMS-0057-F, TEFCA and ONC rules. Use this page as the map of every interoperability service and guide we publish.

For healthcare software companies, payers, provider organizations and health IT teams in the US, with ABDM work for India.

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The short answer

What Healthcare Interoperability Solutions Include

Healthcare interoperability is the ability of separate systems to exchange data and use it without manual re-entry. In practice that means four layers: transport and APIs (FHIR REST, HL7 v2 over MLLP, X12 over a clearinghouse, Direct and document exchange), shared content standards (US Core and USCDI, C-CDA, NCPDP SCRIPT, DICOM), terminology (LOINC, SNOMED CT, RxNorm, ICD-10-CM, CPT) and the operating layer that keeps interfaces running (engines, monitoring, identity matching, consent). Interoperability solutions are the engineering, platforms and support that make those layers work for a specific workflow, such as getting lab results into your app, answering a payer prior authorization in FHIR, or joining a TEFCA network.

Buyer paths

Find the Right Interoperability Service by Problem

Start from what is blocking you. Each path goes to the page that owns that job.

A customer asks: do you integrate with our EHR?

Scope the connection to Epic, Oracle Health, athenahealth, eClinicalWorks, NextGen or MEDITECH, then build and run it.

EHR integration services →

You are a payer facing the January 2027 API deadline

Build the Patient Access, Provider Access, Payer-to-Payer and Prior Authorization APIs that CMS-0057-F requires.

CMS-0057-F implementation →

Hospital HL7 feeds keep failing or your engine is changing

Stabilize, migrate or extend interfaces on Mirth Connect, Rhapsody, Cloverleaf or Corepoint.

HL7 integration services →

Claims, eligibility or remittance data is stuck

Connect 270/271, 276/277, 278, 837 and 835 through your clearinghouse with reconciliation built in.

X12 EDI integration →

You need records from outside your network

Query and exchange through HIEs, Carequality, CommonWell and TEFCA QHINs with consent handled correctly.

TEFCA and QHIN connectivity →

Services and guides

The Interoperability Map: Every Service and Guide

Every interoperability service we deliver, grouped the way buyers search for them.

EHR and EMR Vendors

Vendor access programs, APIs and customer go-live.

Standards: FHIR, HL7, X12, CDA, DICOM, NCPDP

Pick the standard by the job, not by fashion.

Regulations and National Networks

The rules that set deadlines for interoperability work.

Integration Engines and Platforms

Build on the engine you have, or move to a better one.

Clinical and Operational Connections

The data flows around the chart.

Standards

Healthcare Interoperability Standards at a Glance

Most programs combine several of these. The table shows what each carries and where it is required.

StandardWhat it carriesWhere you meet it
FHIR R4 (US Core, SMART, Bulk Data)Resources such as Patient, Observation and Claim over REST and OAuth 2.0ONC (g)(10) certified EHR APIs, CMS-0057-F payer APIs, patient apps
HL7 v2.xEvent messages: ADT, ORM, ORU, SIU, MDM, DFT over MLLPHospital feeds, labs, radiology, charges
X12 5010 EDI270/271, 276/277, 278, 837P/I/D, 835, 999 and 277CAHIPAA-mandated claims, eligibility and remittance
C-CDA R2.1Clinical documents such as CCD and Discharge SummaryTransitions of care, Carequality, CommonWell, Direct
DICOM and DICOMwebImages and imaging metadataPACS, radiology and cardiology systems
NCPDP SCRIPT and TelecommunicationPrescriptions, renewals and pharmacy claimsE-prescribing through Surescripts and pharmacy benefit claims

Regulations

Interoperability Rules and Deadlines to Plan Around

Dates come from the final rules. We build to the requirement and to the implementation guides named in each rule.

CMS-0057-F

Medicare Advantage, Medicaid and CHIP payers must meet prior authorization decision timeframes (72 hours expedited, 7 calendar days standard) from January 1, 2026. Impacted payers, including QHP issuers on the federal exchanges, must run the Provider Access, Payer-to-Payer and Prior Authorization APIs by January 1, 2027.

ONC HTI-1

Certified health IT moves to USCDI v3 as the baseline data standard from January 1, 2026, alongside the (g)(10) standardized FHIR API criterion.

Information blocking

The 21st Century Cures Act lets HHS OIG fine developers and exchanges up to $1 million per violation, and providers face disincentives under the 2024 rule.

TEFCA

Qualified Health Information Networks exchange under the Common Agreement, with FHIR-based exchange being phased in alongside document query.

Buyer decision

Choosing a Healthcare Interoperability Vendor or Approach

Healthcare interoperability vendors fall into four groups. Most organizations use two of them together.

ApproachBest whenTrade-off
Build in-houseIntegration is core to your product and you can hire FHIR, HL7 and X12 specialistsSlow first launch while the team learns vendor programs and customer IT processes
Interface engine (Mirth, Rhapsody, Cloverleaf, Corepoint)Many HL7 v2 feeds inside a health system or labNeeds engine specialists; licensing changed for Mirth Connect 4.6
Integration platform or aggregatorReaching many EHR sites quickly for read-heavy use casesPer-connection pricing and less control over write-back
Interoperability engineering partner (Nirmitee)You need production connections now and want to own the code, mappings and runbooksNeeds a named product owner on your side for workflow decisions

Delivery phases

How Our Interoperability Projects Run

  1. 01

    Discovery

    1 to 2 weeks: systems, workflows, standards, access and owners agreed in writing.

  2. 02

    Access and design

    Vendor program registration, customer interface requests, data mapping and test plan.

  3. 03

    Build and test

    Connectors, mappings and error handling tested against sandboxes and customer test systems.

  4. 04

    Go-live and run

    Cutover with rollback criteria, then monitoring and support, or a full handover.

What Drives Interoperability Project Cost

Systems and sites

Each EHR, payer or lab adds an adapter; each customer site adds configuration and testing.

Direction and depth

Read-only is lighter than write-back, which needs clinical sign-off and partner-level access.

Standards in scope

FHIR plus HL7 v2 plus X12 means three test and monitoring surfaces.

Compliance deadlines

CMS-0057-F or TEFCA dates can require parallel workstreams.

Data history

Backfills and migrations add reconciliation and validation work.

Run model

Handover to your team, or managed monitoring with on-call support.

Delivered work

Interoperability Work We Have Delivered

Client names are withheld; each is a real engagement. Our open-source work is public on GitHub.

Open-source Da Vinci CRD, DTR and PAS Servers

FHIR prior authorization servers for the CMS-0057-F workflow, tested with the Inferno test kits and published on GitHub.

EngagementCMS-0057-F · Open source
View the repository on GitHub →

Open-source Headless EHR on FHIR R4

Passed 47 of 47 ONC (g)(10) SMART App Launch tests in Inferno on 11 June 2026.

EngagementFHIR R4 · SMART App Launch · Open source
View the repository on GitHub →

Behavioral Health Claims Integration Hardening

Claim validation, 999 and 277CA acknowledgement handling and 835 remittance reconciliation for a behavioral health EHR.

EngagementX12 5010 · United States
Read the engineering case study →

Cross-hospital Cancer Case Exchange

A referral and tumour-board exchange across a regional hospital network, where each record stays at its source hospital.

EngagementHospital network · Live across the network

Offline Screening EMR with Device Capture

Readings from connected devices captured offline and reconciled with the central record when the network returns.

EngagementDevice integration · Live in production

FHIR-native Provider Platform

Scheduling, charts, care plans and billing on a FHIR server as the only backend, with single sign-on through OAuth token exchange.

EngagementFHIR R4 · Build
Bring the systems you need to connect. We will map the route, the owners and the first milestone on the call.Book a call

Buyer questions

Healthcare Interoperability FAQ

Read our healthcare integration field guide ↗
What are healthcare interoperability solutions?

Healthcare interoperability solutions are the software, platforms and engineering services that let separate health systems exchange data and use it. They include FHIR APIs, HL7 v2 interfaces, X12 EDI, document exchange, integration engines, terminology mapping, identity matching and the monitoring that keeps interfaces running.

What are the four levels of interoperability in healthcare?

HIMSS describes four levels: foundational (systems can send and receive data), structural (the format is standard, such as HL7 v2 or FHIR), semantic (the meaning is shared through code systems like LOINC and SNOMED CT) and organizational (governance, consent and policy that let organizations trust the exchange).

Which healthcare interoperability standards matter most in the US?

FHIR R4 with US Core and SMART App Launch for APIs, HL7 v2 for hospital event feeds, X12 5010 for claims and eligibility, C-CDA for clinical documents, DICOM for imaging and NCPDP SCRIPT for e-prescribing. USCDI v3 defines the minimum data set certified EHRs must exchange.

How do I choose a healthcare interoperability vendor?

Match the vendor to the job. Interface engines suit many HL7 v2 feeds, aggregators suit fast read access across many EHR sites, and an engineering partner suits production connections you want to own. Ask for public evidence such as Inferno test results or open-source code, a signed BAA, and who runs the interfaces after go-live.

What is a healthcare interoperability platform?

A healthcare interoperability platform is software that hosts connectors, transforms data between standards, routes messages and monitors delivery. Examples range from interface engines such as Mirth Connect and Rhapsody to API platforms. Interoply is our platform for running the integrations we build.

What does CMS-0057-F require, and by when?

CMS-0057-F requires Medicare Advantage organizations, Medicaid and CHIP programs and QHP issuers on the federal exchanges to run Provider Access, Payer-to-Payer and Prior Authorization FHIR APIs, plus an enhanced Patient Access API, by January 1, 2027. Medicare Advantage, Medicaid and CHIP payers must also meet new prior authorization decision timeframes from January 1, 2026.

What is TEFCA and do we need to join?

TEFCA is the national framework for exchange between Qualified Health Information Networks under a Common Agreement. You join through a QHIN, directly or as a participant of one. It matters if you need records from outside your network or must answer treatment and individual access queries.

What is information blocking?

Information blocking is a practice by a provider, health IT developer or exchange that is likely to interfere with access, exchange or use of electronic health information, unless an exception applies. The 21st Century Cures Act defines it, and HHS enforces it with fines for developers and exchanges and disincentives for providers.

What is the difference between HL7 and FHIR?

HL7 v2 is an event-message standard from the 1980s and 1990s that still carries most hospital feeds. FHIR is HL7's modern API standard built on REST, JSON and OAuth 2.0. Most interoperability programs use both, with FHIR for apps and APIs and HL7 v2 for real-time hospital events.

How Much Do Healthcare Interoperability Services Cost?

Cost depends on the number of systems and sites, read-only versus write-back, the standards in scope, compliance deadlines, data history and whether we run the interfaces after go-live. We scope a fixed first phase after discovery instead of quoting a list price.

How do you handle HIPAA and security?

We sign Business Associate Agreements and are ISO 27001:2022 certified. Connections use least-privilege access, encryption in transit and at rest, audit logs of every exchange and synthetic data in development.

Can You Work with Our Existing Integration Engine?

Yes. We build and support interfaces on Mirth Connect, Rhapsody, Infor Cloverleaf and Corepoint, work with Redox, and plan migrations between engines, including moves driven by the Mirth Connect 4.6 license change.

Start the conversation

What Needs to Connect?

Tell us the systems, the workflow and the deadline. We reply with the standards involved, the access you will need and a first milestone.

Prefer to talk it through?

Book a call ↗

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